efficacy and safety of intravenous sodium valproate in convulsive status epilepticus in children in shahid sadoughi hospital

نویسندگان

razieh fallah associate professor of pediatric neurology, department of pediatrics, shahid sadoughi university of medical sciences, yazd, iran

yaser yadegari pediatrics resident, department of pediatrics, shahid sadoughi university of medical sciences, yazd, iran

mahdi salmani nodoushan medical student, ali-ebn-abitaleb school of medicine, islamic azad university, yazd branch, yazd, iran

چکیده

how to cite this article: fallah r, yadegari y, salmani nodushan m. efficacy and safety of intravenous sodium valproate in convulsive status epilepticus in children in shahid sadoughi hospital. iran. j. child. neurol 2012;6(2):39-44.   objective status epilepticus (se) is the most common pediatric neurologic emergency with high mortality and morbidity. there is no consensus on the drug of choice in the treatment of children. the purpose of this study was to evaluate the clinical efficacy and safety of intravenous sodium valproate as a third-line drug in the treatment of generalized convulsive se of children. materials & methods in a retrospective study, medical records of those children who were admitted to shahid sadoughi hospital of yazd due to refractory generalized convulsive se and were treated by intravenous sodium valproate as a third-line drug from 2009 to 2011 were evaluated. results six girls and five boys with a mean age of 5.12 ± 1.2 years (range: 3 - 9.6 years) were evaluated. intravenous valproate was effective for cessation of seizures in seven patients (63.6 %). the mean dose of valproate for stopping seizures was 27.1 ± 1.4 mg/kg/day. children whose seizures were controlled by sodium valproate were older than non- responsive children (mean± sd: 4.8 ± 1.2 years vs. 3.1 ± 0.43 years, p= 0.03) and they also had shorter icu stay days (mean± sd: 2.6 ± 1.4 days vs. 5.6 ± 2.8 days, p= 0.01). two children had mild and transient nausea and vomiting. none of them had cardiopulmonary or severe paraclinical side effects. conclusion intravenous sodium valproate may be used as an effective and safe third-line antiepileptic drug in the treatment of pediatric generalized convulsive status epilepticus. references raj d, gulati s, lodha r. status epilepticus. indian j pediatr 2011;78(2):219-26. shearer p, riviello j. generalized convulsive status epilepticus in adults and children: treatment guidelines and protocols. emerg med clin north am 2011;29(1):51-64. mikati ma. status epilepticus. in: kliegman rm, stanton bf, schor nf, st. geme jw, behrman re. nelson textbook of pediatrics. 19th ed. philadelphia: saunders; 2011. p. 2013-7. nair pp, kalita j, misra uk. status epilepticus: why, what, and how. j postgrad med 2011;57(3):242-52. saz eu, karapinar b, ozcetin m, polat m, tosun a, serdaroglu g et al. convulsive status epilepticus in children: etiology, treatment protocol and outcome. seizure 2011;20(2):115-8. nam sh, lee bl, lee cg, yu hj, joo ey, lee j et al. the role of ketogenic diet in the treatment of refractory status epilepticus. epilepsia 2011;52(11):e181-4. shiloh-malawsky y, fan z, greenwood r, tennison m. successful treatment of childhood prolonged refractory status epilepticus with lacosamide. seizure 2011;20(7):586-8. abend ns, monk hm, licht dj, dlugos dj. intravenous levetiracetam in critically ill children with status epilepticus or acute repetitive seizures. pediatr crit care med 2009;10(4):505-10. chang yc, lin jj, wang hs, chou ml, hung pc, hsieh my. intravenous valproate for seizures in 137 taiwanese children - valproate naive and non-naive. acta neurol taiwan 2010;19(2):100-6. wheless jw, vazquez br, kanner am, ramsay re, morton l, pellock jm. rapid infusion with valproate sodium is well tolerated in patients with epilepsy. neurology 2004;63(8):1507-8. sofou k, kristjánsdóttir r, papachatzakis ne, ahmadzadeh a, uvebrant p. management of prolonged seizures and status epilepticus in childhood: a systematic review. j child neurol 2009;24(8):918-26. visudtibhan a, bhudhisawadi k, vaewpanich j, chulavatnatol s, kaojareon s. pharmacokinetics and clinical application of intravenous valproate in thai epileptic children. brain dev 2011;33(3):189-94. kälviäinen r, eriksson k, parviainen i. refractory generalised convulsive status epilepticus: a guide to treatment. cns drugs 2005;19(9):759-68. arif h, hirsch lj. treatment of status epilepticus. semin neurol 2008;28(3):342-54. misra uk, kalita j, patel r. sodium valproate vs phenytoin in status epilepticus: a pilot study. neurology 2006;67(2):340-2. kwan sy. the role of intravenous valproate in convulsive status epilepticus in the future. acta neurol taiwan 2010;19(2):78-81. aldenkamp a, vigevano f, arzimanoglou a, covanis a. role of valproate across the ages. treatment of epilepsy in children. acta neurol scand suppl 2006;184:1-13. limdi na, shimpi av, faught e, gomez cr, burneo jg. efficacy of rapid iv dministration of valproic acid for status epilepticus. neurology 2005;64(2);353-535. morton ld, o’hara ka, coots bp, pellock jm. safety of rapid intravenous valproate infusion in pediatric patients. pediatr neurol 2007;36(2):81-83. yu kt, mills s, thompson n, cunanan c. safety and efficacy of intravenous valproate in pediatric status epilepticus and acute repetitive seizures. epilepsia 2003;44(5):724-6. trinka e. the use of valproate and new antiepileptic drugs in status epilepticus. epilepsia 2007;48 suppl 8:49-51. chen l, feng p, wang j, liu l, zhou d. intravenous sodium valproate in mainland china for the treatment of diazepam refractory convulsive status epilepticus. j clin neurosci 2009;16(4):524-6. mehta v, singhi p, singhi s. intravenous sodium valproate versus diazepam infusion for the control of refractory status epilepticus in children: a randomized controlled trial. j child neurol 2007;22(10):1191-7. jha s, jose m, patel r. intravenous sodium valproate in status epilepticus. neurol india 2003;51(3):421-2. kanner am. intravenous valproate for status epilepticus. an effective, yet still merely empirical alternative! epilepsy curr 2008;8(3):66-7. russell s. carnitine as an antidote for acute valproate toxicity in children. curr opin pediatr 2007;19(2):206- 10. gilad r, gilad r, izkovitz n, dabby r, rapoport a, sadeh m, et al. treatment of status epilepticus and acute repetitive seizures with i.v. valproic acid vs. phenytoin. acta neurol scand 2008;118(5):296-300.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Evaluation of the efficacy of sodium valproate in convulsive status epilepticus following to ıschemic stroke.

OBJECTIVE Convulsive status epilepticus (CSE) is very rarely observed after ischaemic stroke. Sodium valproate (SV) is one of the agents used in the treatment of CSE, but its role still controversial, and its degree of efficacy in treating CSE that develops following stroke is unclear. METHOD We evaluated 19 patients who were treated with intravenous (IV) SV (20 mg/kg, 2 mg/kg/h-12h) after di...

متن کامل

norms and ideology in translation of children literature in persian context

اهداف عمده ی این مطالعه دو دسته هستند:1) تعیین هنجار های اجتماعی فرهنگی مورد استفاده در ترجمه ی کتاب کودک برای کودکان ایرانی 2) بررسی مفهوم کودک در ایران و ائدئولوژی این جامعه در رابطه با کودک که مترجم را مجبور به بازسازی کتابهای داستان برای کودکان ایرانی میکند. به این منظور, ابتدا ,مجموعه ای از 30 کتاب داستان و ترجمه های فارسی انها بر اساس مدلlambert and van gorp(2006)مقایسه شد و سپس استراتژیه...

15 صفحه اول

The role of intravenous valproate in convulsive status epilepticus in the future.

Acta Neurologica Taiwanica Vol 19 No 2 June 2010 From the Department of Neurology, Taipei Veterans General Hospital, Taipei Taiwan. Received May 31, 2010. Revised and Accepted May 31, 2010. Reprint requests and correspondence to: Shang-Yeong Kwan, MD. Department of Neurology, Taipei Veterans General Hospital, 16F, No. 201, Section 2, Shipai Rd., Taipei Taiwan. E-mail: [email protected] The R...

متن کامل

a comparative assessment the efficacy of intravenous infusion of sodium valproate and phenytion in the treatment of status epilepticus

background: status epilepticus (se) is a type of persistent lasting seizure with high mortality and morbidity. numerous medications are suggested for the treatment of se, two of which are sodium valproate and phenytoin. the purpose of this study is to conduct a comparison between the effi ciencies of intravenous sodium valproate and phenytoin in the treatment of this type of epilepsy. methods: ...

متن کامل

Convulsive status epilepticus in Thai children at Ramathibodi Hospital.

BACKGROUND Convulsive Status Epilepticus (SE) is an emergency neurological condition with high morbidity and mortality. The outcome of this condition in children depends on the etiology and the duration of convulsion. There is no report of this condition in Thai children. OBJECTIVE To study the etiology, clinical course and outcome in children with convulsive SE in a referral hospital in Thai...

متن کامل

Efficacy and Safety of Intravenous Valproate for Status Epilepticus: A Systematic Review

INTRODUCTION The effectiveness of valproate (VPA) in the treatment of focal and generalized epilepsies is well established. The drug has a wide spectrum of action, good tolerability, and has been available as an injectable formulation since 1993. Despite the lack of class A evidence, it has been used extensively in various forms of status epilepticus (SE). AIM Our aim was to present a systema...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of child neurology

جلد ۶، شماره ۲، صفحات ۳۹-۴۴

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023